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Amy Cullen is the daughter of FBI Director Sam Cullen.
Her first appearance was in The Graft in the Girl when Booth and Brennan visit her father at the hospital in which she is staying. It is revealed that Amy was diagnosed with Mesothelioma, a rare lung cancer, after receiving a bone graft due a snowboarding accident. The graft turns out to be from an elderly man who died of Mesothelioma, and whose bones were sold illegally. Throughout the episode, Amy becomes close to fellow artist Angela Montenegro, who admires her work, and gives her advice on life and love. At the end of the episode, Angela brings Amy a virtual reality headset, so she could visit the Louvre without leaving the hospital.
Amy's status is unknown, as during the episode she is quite weak (one of the doctors informs Amy's parents that the most recent treatment they tried hadn't worked), and it is hinted she probably wouldn't survive. Bones even told Angela that Amy is left in the same condition she was before, just with answers.